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History

The interaction database is based on the professional work of P.K.M. Lunde, Olav Spigset, Espen Molden and many others over more than 30 years. The website interaksjoner.net and the DRUID (Drug Information Database) were originally a collaboration between Ivar Aursnes and Per Johan Næsje at the Institute of Pharmacotherapy at the University of Oslo, Olav Spigset at the Drug Department at the Regional Hospital in Trondheim (now St. Olav's Hospital), and Khang Nguyen and Magne Rekdal at Pfizer AS, initiated by the latter.
  • Launched in 2000, coordinated with the annual work by Spigset for the Norwegian Medicines Handbook.
  • In 2005 the operational responsibility was moved from the Institute of Pharmacotherapy to Emetra AS.
  • In 2012 the Norwegian Medicines Agency (now DMP) took over maintenance of the two databases DRUID and Apriori.
    This formed the basis for the interactions part of FEST (Prescribing and Dispensing Support).
  • As of April 2012, the content of the interaction database is exclusively based on data from FEST.
  • In 2015 Emetra AS was acquired by and merged with DIPS AS, which thereby took over operational responsibility.
  • As of April 2026, operational responsibility rests with Whitebrook AS, a company owned by Magne Rekdal.

Updates

The database is updated twice a month with interaction data from FEST. It is updated daily with trade names from a number of countries, although not all sources are updated continuously. Except for the USA, all data come from the respective national medicines agencies.
  • Nordic: Denmark, Finland, Iceland, Norway and Sweden.
  • Other Europe: Belgium, Estonia, France, Ireland, Italy, Croatia, Latvia, Lithuania, Luxembourg, Netherlands, Poland, Romania, Serbia, Slovenia, Spain, United Kingdom, Switzerland, Czech Republic and Hungary.
  • Outside Europe: Canada, Colombia, New Zealand and the USA.
In addition to automatic import, all data undergo a manual process to remove information from sources that is of little relevance, such as company names, strengths, formulations, etc.

Contact information

For scientific questions, please contact the Norwegian Medicines Agency and the FEST editorial team. For technical questions or operational issues, contact Magne Rekdal at Whitebrook AS.

CombiMed is based on data from FEST provided by The Norwegian Medicines Agency in Norway. Whitebrook AS delivers the solution to the best of its ability but takes no responsibility for any errors in the service, errors in the scientific content, or for damages that arise from use of the service. Additional information from other sources should be used in case of doubt, and sound clinical judgement is always necessary.

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